Projects

2019

NEUro fMRI biomarkers for TReatment Navigation in Depression (NEUROTREND)




Research during the last decade identified MRI-outcomes as potential powerful biomarkers (i.e. the connectome signatures in fMRI Lui et al., 2011). In our own work, connectivity changed as a consequence of neurostimulation (repetitive TMS) showing a functional reorganisation from a high clustered (dense connected) default mode brain network to a more steady state after neurostimulation only in responders. The goal of this project is to further develop and validate MRI-based biomarkers for diagnosis and treatment stratification of depression

For more information, click here.

Priming the Epileptic brain (PREP)




The goal of this study is to determine the priming effect on the epileptic brain of transcutaneous vagal nerve stimulation (tVNS), to make it more susceptible to add-on treatment with Brivaracetam (BRV), an anti-epileptic drug (AED). In addition, we aim to visualize these changes in the brain because of priming, possibly altered network-organisation.

For more information, click here.

PerStim: personalized neurostimulation for non-invasive epilepsy treatment




Neurostimulation is a promising treatment method for patients with epilepsy, of whom approximately 30 percent still suffer from seizures, in spite of medication. Based on a novel EEG-based non-invasive neurostimulation system, we investigate how we can effectively personalize treatments for patients with focal epilepsy.

For more information, click here.